Sustainable weight loss

Addressing what happens
after weight loss

We are building next-generation obesity treatments designed to sustain results, helping patients maintain progress over time through better biology and a more practical approach to real-world use.

Alveus Therapeutics is focused on what comes next in metabolic medicine

~1.5B adults living with obesity by 2035
10-15% of eligible obese patients are currently treated with incretins
4 times a year the number of injections ALV-100 may require for maintenance
~100+ years of combined leadership team experience in the metabolic field
Our science

The science exists
– we address the gaps

We follow the genome

Every mechanism we pursue is anchored in validated biology. For our lead asset, ALV-100, human genetics shows that reducing GIPR activity can help protect against obesity, heart disease, and metabolic complications – through a pathway distinct from GLP-1.

A shot every three months

ALV-100 is designed for quarterly maintenance dosing, a longer interval than other obesity assets in clinical development. That is not an incremental improvement. That is a fundamentally different life for patients.

Differentiated Pipeline

ALV-100 plus two proprietary amylin programs, a selective injectable peptide and an oral small molecule, provide multiple shots on goal in the largest therapeutic market of the decade.

Our treatments focus on long-term weight maintenance, while supporting safe and patient-friendly weight loss

Development pipeline

A differentiated therapeutic portfolio
built for every patient journey

Addressing core unmet needs

We have created a portfolio designed to support the desire of patients for quality weight loss, improved tolerability, and people-friendly dosing regimens. Enabling a positive patient experience places us on a clear path to transform the next generation of obesity therapy.

Our pipeline
ALV-100 GIPR antagonism + GLP-1R agonism
ALV-200 AMYR3-selective peptide
ALV-300 Dual amylin-calcitonin receptor agonist (DACRA) small molecule
Fourth program Novel amylin agonist modality
Alveus Leadership

A proven track record of advancing medicines and building companies

Our board and leadership team bring deep expertise, spanning discovery, development manufacturing, commercialization, financing, and M&A.

Meet our people

Every program starts with a molecule, and is carried forward by a team, a strategy, and an unrelenting commitment to patients.

Read about our science
Investors & Partners

Backed by the best in biotech

Series A Investors